Case Presentation: Hemophagocytic lymphohystiocytosis (HLH) is a rare cause of pancytopenia. Patients with sickle cell disease can present with pancytopenia and recognition of (HLH) in patients with sickle cell disease may be a lifesaving diagnosis.Case presentation:A 39-year-old female with past medical history of sickle cell anemia and moyamoya disease was admitted with sickle cell vaso-occlusive […]

Case Presentation: This is a 4-year-old previously healthy girl, fully immunized with the exception of COVID-19 immunizations, who was hospitalized after presenting with fevers and fatigue for one week followed by gross hematuria. At the outset of her fevers, she tested negative for COVID-19 using a home antigen test. 4 days prior to admission, she […]

Background: Anemia is a risk factor for cognitive impairment as a result of the reduced delivery of oxygen to the brain from low hemoglobin (Hb) levels. In ambulatory patients even mild anemia (Hb < 12g/dL) has been associated with reductions in patients’ cognitive function. However, in hospitalized patients it is standard of care to maintain […]

Background: Mental fatigability is a measure of an individual’s susceptibility to increased mental fatigue resulting from engaging in physical and/or mental activities. Mental fatigability is important in hospitalized patients because it is has been shown to be associated with reduced physical activity levels, and reduced activity directly contributes to hospital associated disability and reduced functional […]

Background: Anemia is an acute and/or chronic condition with a range of underlying etiologies present in an estimated 40-70% of hospitalized patients. While comprehensive diagnostic and treatment algorithms for anemia exist, they are rarely used by hospitalist clinicians in the inpatient setting. This is because these algorithms were derived in ambulatory patients where acute anemia […]

Background: Chronic heart failure (CHF) patients with reduced ejection fraction (EF), as defined as EF < 50%, and iron deficiency have shown improvements in symptoms, functional capacity, and quality of life when treated with IV iron, even without overt anemia (1). The FAIR-HF (2009) and CONFIRM-HF (2015) studies showed improvements in New York Heart Association […]

Case Presentation: An 80-year-old man with a past medical history of hypertension, benign prostatic hyperplasia, and hypothyroidism, presented to the emergency department due to a sudden loss of consciousness. The episode lasted a few minutes and was not associated with trauma, prodrome, seizure, or postictal confusion. Patient had recently been prescribed phenazopyridine for a suspected […]

Case Presentation: Patient is a 71-year-old female who presented to the emergency department due to outpatient labs showing a significant anemia. Her primary complaint was a worsening feeling of generalized weakness over the last four weeks. She denied blood in her stool or urine, or any history of bleeding or clotting disorders. She was found […]

Case Presentation: A 75-year-old male with a history of type 2 diabetes mellitus, atrial fibrillation and hypertension presents to the hospital for evaluation of generalized weakness. He was found to have significant anemia with hemoglobin of 6.5 g/dL. He has had multiple admissions for anemia, and in the last year has required over twenty blood […]

Case Presentation: A 65-year-old woman with a history of early-stage breast cancer—was treated six years prior. She was subsequently admitted multiple times over the following years for pancytopenia, which was thought to be multifactorial—due to nonalcoholic steatohepatitis and auto-immune hemolytic anemia (AIHA). Therefore, she received a supportive blood transfusion, intravenous immunoglobulins, and rituximab for suspected […]