Background: Systemic muscle relaxant prescriptions have risen in United States. Baclofen is a commonly prescribed muscle relaxant that is gamma-aminobutyric acid (GABA) agonist and renally cleared. We aimed to determine the risk of encephalopathy and mortality associated with baclofen compared to an alternate muscle relaxant cyclobenzaprine in a real-world setting. Methods: We conducted a retrospective […]

Background: Evidence-based COVID-19 management has evolved with unprecedented speed; however, the rate and fidelity with which institutions have adopted new evidence into practice is unknown. Methods: We surveyed members of the Hospital Medicine Reengineering Network (HOMERuN) from 12/17/20-2/10/21 and compared their institutional COVID-19 management recommendations to available evidence from pivotal randomized controlled trials (RCTs) and […]

Background: Communication, teamwork, and conflict navigation amongst physician colleagues are core competencies. Yet, how these core elements of professional behavior are enacted in practice remains poorly characterized, and interpersonal interactions continue to be a central source of workplace conflict. While this has been described in the nursing literature, physicians’ experience of conflict with other physician […]

Background: Acknowledging that a successful career in hospital medicine (HM) may require specialized skills, residency programs have developed hospital medicine-focused education (HMFE) programs. Surveys of internal medicine residency leaders have described HMFE curricula but are limited to that specialty and lack input from early career hospitalists (ECHs) who recently completed this training. Therefore, we surveyed […]

Background: Central nervous system medication (CNS med) use among older adults is associated with high morbidity and mortality. This study described patterns of CNS medication use, and identified people most likely to have CNS medications initiated or deprescribed around hospitalization. Methods: Retrospective cohort study using electronic health record data from 3-hospitals. Patients aged 65 years […]

Background: Recurrent Clostridioides difficile infection (rCDI) is an urgent public health threat. RBX2660 is a standardized, stabilized, investigational microbiota-based live biotherapeutic that has been evaluated in 5 prospective clinical trials. Eligibility criteria in clinical trials are often narrowly defined, excluding broader patient populations. Herein, we report a retrospective analysis of safety and efficacy of RBX2660 […]

Background: The COVID-19 pandemic has brought unprecedented changes to the way healthcare is delivered. While the impact of death and comorbidity due to infections with SARS-CoV-2 is a ubiquitous concern, it is unclear what effect this pandemic is having on hospitalized patients who are not infected with the SARS-CoV-2 virus. We seek to estimate the […]

Background: Sepsis is a leading health care burden associated with high mortality in the United States. Poor outcomes associated with sepsis continue despite modifications in the sepsis care guidelines. Several factors influence the outcome of sepsis including patient characteristics, etiology of sepsis, and management in the appropriate intensive care unit setting. The aim of our […]

Background: Arterial (3-fold) and venous (10-fold) thromboembolism are more common in myeloproliferative neoplasm (MPN) than general population with rates as high as 50% in polycythemia vera (PV) and essential thrombocythemia (ET).1,2 While primary prophylaxis with aspirin is not debated for prevention of arterial and venous thromboembolism, the choice of anticoagulant for secondary prophylaxis and treatment […]

Background: The COVID-19 pandemic has placed additional stress on the healthcare system. Not only do we face large volumes of high acuity patients, but also acute shortages of healthcare providers. Physician shortages were particularly pressing to our institution. COVID-19 patients were cohorted to our Hospital Medicine (MHS) service to minimize exposure and risks to house […]