Background: Clostridioides difficile infection (CDI) is a common, often nosocomial infection associated with substantial morbidity and mortality. Antibiotics are the most important modifiable risk factor, but empiric antibiotics remain appropriate for many patients with severe acute illness. Which antibiotics minimize the risk of CDI remains an important unanswered question. Because protective equipment and isolation were [...]

Background: Timely identification and treatment are integral to sepsis management in emergency department (ED) and inpatient settings. Increasingly, automated alerts embedded in electronic health records (EHRs) are used to expedite sepsis detection but may lead to false alarms and increased alarm fatigue. Additionally, recent data have demonstrated that the EPIC Sepsis Model—a proprietary sepsis alert [...]

Background: Clostridioides difficile infection (CDI) is a common, often nosocomial infection associated with substantial morbidity and mortality. Antibiotics are the most important modifiable risk factor, but empiric antibiotics remain appropriate for many patients with severe acute illness. Which antibiotics minimize the risk of CDI remains an important unanswered question. Because protective equipment and isolation were [...]

Case Presentation: Prosthetic valve endocarditis (PVE) is predominantly caused by staphylococcus aureusand streptococcus viridian. Infective endocarditis (IE) due to Burkholderia cepacia israre. We present a case of a 27-year-old man with history of injection drug use, IE of aorticand mitral valve status post replacement with bioprosthetic valves 6 months ago, whopresented with fever, chills, dyspnea and [...]