Background: Patients with end stage renal disease (ESRD) are at significantly increased risk for both thrombosis and bleeding relative to those with normal renal function, which makes anticoagulation particularly challenging. Evidence suggests that rivaroxaban and dabigatran are associated with a higher risk of bleeding in ESRD patients. To date, no large national cohort studies have […]

Background: Systemic muscle relaxant prescriptions have risen in United States. Baclofen is a commonly prescribed muscle relaxant that is gamma-aminobutyric acid (GABA) agonist and renally cleared. We aimed to determine the risk of encephalopathy and mortality associated with baclofen compared to an alternate muscle relaxant cyclobenzaprine in a real-world setting. Methods: We conducted a retrospective […]

Background: Epidemiology of Non-Variceal Upper Gastrointestinal Bleeding (NVUGIB) such as peptic ulcer bleeding, Mallory-Weiss tear, erosive gastritis/duodenitis, oesophagitis/oesophageal ulcer is well known among general population. However, data is lacking about its trend among Cirrhotic population in literature. No large database study is available to compare prevalence, predictors, and outcomes of NVUGIB among Cirrhotic patients. We […]