Case Presentation: A 19-year-old male with recent diagnosis of human immunodeficiency virus (HIV) (CD4 580/mm³ and viral load 1.2 million/mm³) and Kaposi sarcoma (KS) was transferred to our hospital for refractory thrombocytopenia. Prior to his presentation, he experienced a month of fatigue, night sweats, weight loss, and facial and neck swelling. His outside hospital workup [...]