Case Presentation: A 70-year-old male with medical history significant for rheumatoid arthritis presented to the emergency department with several days of odynophagia, oral ulcers, skin lesions and epistaxis. He was treated for foot cellulitis with TMP-SMX for one week prior to admission. The patient had been receiving 10 mg SQ weekly injectable MTX for Rheumatoid […]

Case Presentation: A 26-year-old otherwise healthy female was prescribed trimethoprim-sulfamethoxazole (TMP-SMX) for a recurring, spontaneously draining vaginal mass below her urethra with inguinal adenopathy. 5 days after starting TMP-SMX, she developed a full-body rash, fever, myalgia, nausea, and a depressed WBC of 2.4 K/mcL. Possible drug fever was suspected and TMP-SMX was discontinued and covered […]

Case Presentation: A 31-year-old male with no significant past medical history presented with fever, chills, night sweats, and rash. One week prior, he underwent incision and drainage of a perirectal abscess and was started on a 7-day course of trimethoprim/sulfamethoxazole (TMP-SMX). On the second day following the procedure, he developed fevers, chills, night sweats, and […]