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Search2020-05-20T12:01:36-05:00
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Abstract Number: G6
EFFICACY OF METHYLNALTREXONE IN PATIENTS WITH ADVANCED ILLNESS AND OPIOID-INDUCED CONSTIPATION REFRACTORY TO CONVENTIONAL LAXATIVES: IMPACT OF BASELINE LAXATIVE USE
SHM Converge 2022
Background: Methylnaltrexone (MNTX) is a peripherally acting µ-opioid receptor antagonist indicated for opioid-induced constipation (OIC). We evaluated whether baseline use of laxatives, including stimulants, osmotic agents, stool softeners, or combinations thereof affects the efficacy and safety of MNTX. Methods: This post hoc analysis included pooled data from 2 multicenter, randomized, double-blind, placebo (PBO)-controlled, institutional review […]
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