Case Presentation: This case describes a 63-year-old male who was recently diagnosed with renal cell carcinoma with metastasis to the lungs confirmed with a biopsy showing diffuse PAX-8 positivity on an immunohistochemical staining panel favoring renal origin. He was started on Nivolumab/Ipilimumab however was hospitalized in the intensive care unit for septic shock due to [...]