Case Presentation: A 57-year-old man with depression and prior suicide attempts presented after being found unresponsive at home with empty bottles of doxepin, amitriptyline, and another unidentified pill bottle. In the ED, he had a GCS of 6, was intubated for airway protection and admitted to MICU. Sodium bicarbonate, fentanyl and propofol infusions were started [...]