Case Presentation: A 32-year-old woman with sickle cell HbSS disease presented due to acute encephalopathy in the setting of recent admission for diffuse urticarial rash treated with steroids and diphenhydramine. She was found to be hypotensive, tachycardic, and tachypneic with development of fever soon after presentation. Chest x-ray showed left basilar opacities. She was intubated [...]