Case Presentation: This case investigates the etiology of acute interstitial nephritis (AIN) in a metastatic melanoma patient who was transitioned from immune-checkpoint inhibitors (ICIs) to targeted BRAF-MEK inhibitors (BRAFi/MEKi). A 73-year-old man with cutaneous melanoma with lung metastases presented to the emergency room for generalized weakness, fevers, and renal failure. Six weeks prior to his [...]