Case Presentation: A 41-year-old man with end-stage renal disease (ESRD), hypertension, hyperlipidemia, and hepatitis B-induced liver cirrhosis was evaluated after a computed tomography (CT) scan of his abdomen revealed an unexpected finding of cardiomegaly with moderate to large pericardial effusion. Subsequent transthoracic echocardiograms revealed moderate pericardial effusion without tamponade physiology but with increased interventricular septal [...]