Background: Over 32 million patients in the United States have a penicillin (PCN) allergy label in their medical chart.1 Studies have demonstrated that 15-20% of hospitalized patients are labeled PCN allergic. However, IgE-mediated PCN allergy wanes over time and up to 80% of patients with a listed PCN allergy can tolerate PCN after 10 years. [...]

Background: Penicillin is the most commonly documented drug “allergy” on hospital admission. Patients with listed penicillin allergies have higher rates of treatment failures, antibiotic resistance, and average length of stay. This has downstream implications impacting healthcare utilization, infection prevalence, and cost. However, the majority of these reported allergies are inaccurate, and over 90% of these [...]

Case Presentation: A 72-year-old HIV-negative male with a past medical history of neurosyphilis who received two complete 2-week regimens of IV Penicillin G and one IM Penicillin, was admitted due to a recurrence of blurry vision and gait instability. The patient’s symptoms started with dizziness noted since last year, which then progressed to gait instability [...]