Background: Acute heart failure exacerbations are a leading cause of morbidity and mortality, with high rates of hospitalization and healthcare expenditure. Guideline-directed medical therapy (GDMT) has improved outcomes in heart failure with reduced ejection fraction (HFrEF), improved ejection fraction (HFimpEF), preserved ejection fraction (HFpEF), and moderately reduced ejection fraction (HFmrEF). Recent studies highlight the benefits [...]