Background: Thrombotic thrombocytopenic purpura (TTP) is a rare but deadly thrombotic microangiopathy (TMA) that is caused by ADAMTS13 deficiency. The PLASMIC clinical scoring system was developed and validated to determine the pretest probability of severe ADAMTS13 deficiency in cases of suspected TTP. We studied the role of the PLASMIC score in guiding use of the [...]

Case Presentation: A 77-year-old African-American male with Adult-onset Still’s disease (AOSD) was admitted at the hospital for severe thrombocytopenia. The patient had been diagnosed with AOSD four years before this hospital admission. His AOSD was well-controlled with anakinra, an interleukin-1 receptor antagonist, and low-dose prednisone. On admission, the patient did not have any neurological manifestation. [...]