Background: Acute heart failure (AHF) exacerbations are a leading cause of hospitalization in the United States. Despite the frequency of AHF hospitalizations, there are inadequate data or practice guidelines on how quickly diuresis should be achieved. Methods: We conducted a pooled cohort study using data from three acute heart failure trials (DOSE, ROSE, and ATHENA-HF). [...]

Background: Acute heart failure (AHF) exacerbations are a leading cause of hospitalization in the United States. Despite the frequency of AHF hospitalizations, there are inadequate data or practice guidelines on how quickly diuresis should be achieved. Methods: We conducted a pooled cohort study using data from three acute heart failure trials (DOSE, ROSE, and ATHENA-HF). [...]

Case Presentation: The patient was a 73 year old gentleman with a recent diagnosis of heart failure with preserved ejection fraction presenting with weight gain, worsening dyspnea, lower extremity edema, and urinary incontinence since beginning furosemide two months previously. Labs were notable for a creatinine of 2.68 mg/dL from a baseline of 1.0 mg/dL. The [...]

Background: Acute Decompensated Heart Failure (ADHF) is responsible for over a million hospitalizations per year in the US and Europe. The American Heart Association Guidelines for treatment of patients hospitalized with ADHF recommend intravenous (IV) diuresis with loop diuretics to reduce fluid overload until vascular congestion is relieved. However, the optimal dosing strategy for IV [...]