Background: Urinary tract infection (UTI) is the most common infection associated with antibiotic misuse. Catheter-associated UTI (CAUTI) is the largest reservoir of nosocomial antibiotic-resistant pathogens, including Pseudomonas aeruginosa. Health-care associated urinary tract infection is also a known risk factor for antibiotic-resistant bacteria, and an important entity that has yet to be characterized. The aim of [...]

Background: Between 2007 and 2015, inpatient fluoroquinolone use declined in U.S. Veterans Affairs (VA) hospitals. Whether fluoroquinolone use at discharge has also declined, in particular since antibiotic stewardship programs became mandated at VA hospitals in 2014, is unknown. Methods: In this retrospective cohort study of hospitalizations with infection between January 1, 2014 and December 31, [...]

Background: Uncomplicated Urinary Tract Infections (UTIs) account for more than 100,000 inpatient admissions yearly. IDSA guidelines recommend Nitrofurantoin as first line therapy and recent FDA guidelines recommend against Fluoroquinolone (FQ) use due their side effects and growing resistance; however, Sulfamethoxazole/Trimethoprim (Bactrim) and Ciprofloxacin are still commonly used to treat uncomplicated UTIs. Therefore we hypothesized that [...]