Case Presentation: A 26-year-old male with HbSS sickle cell disease and a history of recurrent hospitalizations for vaso-occlusive crises, requiring a right chest port for pain management and IV fluids, presented with sepsis and an acute vaso-occlusive crisis. Initial infectious workup, including chest X-ray, CT of the chest, abdomen, and pelvis, and urinalysis, was unremarkable. [...]