Background: Adolescent e-cigarette use was declared as an epidemic by the U.S. Surgeon general in 2018 and has severe health consequences, including e-cigarette, or vaping, product use-associated lung injury (EVALI). It is known that e-cigarette use is associated with mental health disorders and psychosocial stressors; however, there is a knowledge gap in characterizing psychosocial stressors [...]

Background: Social isolation and loneliness (SI+L), two largely silent social determinants of health (SDOH), are associated with negative health outcomes such as the increased risk of cardiovascular disease, higher rates of depression, increased hospital readmissions, and increased use of healthcare services. SI+L are also common, with one in five US adults reporting feelings of SI [...]