Case Presentation: A 73-year-old male with history of type 2 diabetes and one-month prior admission for acute renal failure in the setting of stage IV chronic kidney disease presented with symptomatic anemia found to have splenomegaly. A renal biopsy revealed features of membranoproliferative glomerulonephritis and necrotizing crescentic lesions with IgM kappa deposition, suspicious for cryoglobulinemic glomerulonephritis. Immunofixation [...]

Case Presentation: A 24-year-old African-American woman presented with nausea, flank pain, and hematuria recurring over several months. Review of symptoms and past medical history were negative. She was a current smoker. Family history was noncontributory. Physical exam was significant for bilateral flank pain. Laboratory testing, serology, and kidney biopsy led to the diagnosis of rapidly [...]

Case Presentation: A 64-year-old female with hereditary transthyretin amyloidosis (hATTR) and hypothyroidism presented with three days of dull pain localized bilaterally to the biceps femorum, recurrent emesis, and anorexia. Her past medical history includes complications of hATTR (being treated with patisirtan and tafamidis); polyneuropathy, small bowel enteropathy, and cardiomyopathy with associated recent bioprosthetic mitral and [...]

Case Presentation: A 72-year-old male presented to the emergency room for macrocytic anemia and a creatinine of 9.72 mg/dL on outpatient lab work. Past medical history was notable for paroxysmal supraventricular tachycardia, gastroesophageal reflux disease and heart failure with reduced ejection fraction. On admission, he complained of six months of fatigue with constipation, 60 lbs [...]