Background: Gabapentinoids (gabapentin and pregabalin) are commonly prescribed medications typically used to treat neuropathic pain. They are often prescribed off label with varying degrees of evidence to treat a variety of other conditions such as non-neuropathic pain, post-operative pain, and alcohol use disorder. Due to emerging evidence, in 2019 the FDA put out a warning [...]

Case Presentation: A 65 year old male with a history of diabetes mellitus type II complicated by neuropathy presented with profound facial and oropharyngeal edema after ingesting his usual medications. He was hemodynamically stable and without urticaria on exam. The patient could not speak and his airway was deemed compromised, so he underwent urgent nasopharyngeal [...]

Background: In 2019, the US Food & Drug Administration issued a warning regarding safety of gabapentin use in patients with respiratory conditions, including chronic obstructive pulmonary disease (COPD). Gabapentin is widely prescribed, often for off-label indications, however limited data exist regarding safety and outcomes among patients with COPD. Methods: We analyzed data from 29 US [...]