Background: Methylnaltrexone (MNTX) is a peripherally acting µ-opioid receptor antagonist indicated for opioid-induced constipation (OIC). We evaluated whether baseline use of laxatives, including stimulants, osmotic agents, stool softeners, or combinations thereof affects the efficacy and safety of MNTX. Methods: This post hoc analysis included pooled data from 2 multicenter, randomized, double-blind, placebo (PBO)-controlled, institutional review [...]

Case Presentation: A 30-year-old female with medical history of constipation with chronic laxative use presented with complaints of peripheral edema and weight gain. Patient had been using stimulant laxatives for 4 years but stopped 1-week prior to presentation due to painless bright-red blood per rectum. She initially presented to the emergency department 7 days after [...]