Case Presentation:       A 33 year-old Hispanic male without significant history presented with an unremitting fever for 5 days, associated with myalgais, fatigue, night sweats, and a rash. Upon admission, he was tachycardic, hypotensive and febrile at 103F. Physical exam revealed a diffuse non-blanching, maculo-papular rash, sparing the face, palms and soles. Labs [...]

Case Presentation: A 36-year-old Caucasian male, a construction worker, presented with three weeks of high-spiking daily fevers, myalgias and fatigue. He endorsed a water-skiing trip, and tick and dog bites within recent weeks. He was discharged two days prior from an outside hospital (OH), where he was treated for possible pneumonia or a tick-borne illness [...]

Case Presentation: A 43-year-old man presented to the hospital with three days of lethargy, confusion, jaundice, abdominal pain with associated vomiting and poor oral intake. Medical history includes recently diagnosed Adult-onset Still’s Disease (AOSD) 6 weeks prior to presentation, for which he was taking prednisone 60 mg daily. Exam was notable for lethargy, petechiae on [...]

Case Presentation: A 38-year-old male with presumed seronegative rheumatoid arthritis (RA), irritable bowel syndrome with diarrhea (IBS-D), and reported Lyme disease (negative serology) presented with acute dyspnea, pleuritic chest pain, and chronic relapsing fevers. Initial treatment with broad-spectrum antibiotics failed, and he developed acute hypoxic respiratory failure, requiring transfer to the Medical Intensive Care Unit [...]

Case Presentation: A 25-year-old woman with autism, developmental delay, and seizure disorder presented with weakness, joint pain, and lethargy. Initial findings included pancytopenia, elevated inflammatory markers, and hyperferritinemia. She was diagnosed with hemophagocytic lymphohistiocytosis (HLH) secondary to adult-onset Still’s disease. Despite treatment with corticosteroids, anakinra, and tocilizumab, her condition worsened, necessitating ICU admission. Discussion: HLH [...]