Case Presentation: A 33-year-old woman with a past medical history of a calcaneal fracture requiring internal fixation complicated by poor wound healing and repair with a free flap, and polymicrobial osteomyelitis on home amoxicillin-clavulanate and IV daptomycin presented with three days of fevers, chills, and generalized malaise. She reported adherence to her home antibiotic regimen. [...]

Case Presentation: A 69 year old woman presented to the hospital with 2 days of progressively worsening right lower leg pain and rash. Other symptoms included persistent nausea & vomiting following a recent episode of gastroenteritis. Exam demonstrated normal vital signs and bilateral lower extremity edema extending to the knees with apparently equal bilateral tenderness. [...]

Case Presentation: A 19 year-old college student presented with fevers, chills, and a sore throat for the past 7 days. She had no significant past medical history and was healthy at baseline. She denied any illicit or intravenous drug use. Her vitals were notable for a temperature of 102.4F and heart rate 115 bpm. On [...]

Case Presentation: INTRODUCTION: Disseminated gonococcal infection presents as either purulent monoarticular arthritis or as tenosynovitis, migratory polyarthralgia and vesiculopustular rash in young sexually active adults. We present an unusual case of disseminated gonococcal infection presenting as petechial rash, tenosynovitis and polyarthralgia with hypocomplementemia in a middle woman.CASE PRESENTATION: 46 years old woman medical history of [...]

Case Presentation: A 77-year-old male with chronic kidney disease and mitral valve prolapse with a history of Lyme disease and West Nile Virus presented with fevers, night sweats, chills, and fatigue for 3 weeks. The patient had been visiting family in Texas for one month but gradually started to notice his symptoms. A few weeks [...]

Background: Clostridioides difficile infection (CDI) is a leading healthcare-associated infection causing debilitating diarrhea, life-threatening complications, 20,500 deaths and healthcare costs of up to $5.4 billion annually in the US. The main driver of CDI costs is hospitalizations, and patients with higher CDI recurrence rates have more hospitalizations and emergency department visits and longer hospital stays. [...]

Background: As hospitals focus on central venous catheter associated bloodstream infections (CVC-BSI), the impact of peripheral venous catheter (PVC) associated bloodstream infections (PVC-BSI) may be underappreciated. There are conflicting recommendations on how to manage PVCs, including when to replace them (1)(2)(3), and inconsistencies in nursing practice in following PVC management guidelines (4). There are an [...]

Case Presentation: A 54-year-old man with a past medical history of intravenous drug use and morbid obesity presented with worsening bilateral lower leg pain and swelling. The patient reported chronic bilateral leg edema after a car accident a year before and started noticing skin changes with multiple bumps on his legs for several months. He [...]

Case Presentation: A 68-year-old man with a history of cryptogenic cirrhosis and hepatocellular carcinoma status post liver transplant with donor positive for cytomegalovirus (CMV), and recent treated CMV reactivation, was transferred from a nearby hospital with acute hypoxic respiratory failure requiring intubation secondary to Pneumocystis jirovecii pneumonia (PJP) identified on bronchoalveolar lavage. He was treated [...]

Background: Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is an orally bioavailable prodrug that is rapidly converted in plasma to the carbapenem, tebipenem. Tebipenem has in vitro activity against select multidrug-resistant Gram-negative pathogens, including fluoroquinolone-resistant and extended-spectrum ß-lactamase (ESBL)-producing Enterobacterales. TBP-PI-HBr is being developed in the United States as the first oral carbapenem for treatment of cUTI and [...]