Background: Osteomyelitis is an acute or chronic infection of the bone structures which can be caused by either bacteria, fungi, or mycobacteria. Studies have reported a high annual incident of about 1 in 675 hospital admission in the United States. The overall incident is higher in the male population for reasons unclear and increases with […]

Background: The COVID-19 pandemic has brought unprecedented changes to the way healthcare is delivered. While the impact of death and comorbidity due to infections with SARS-CoV-2 is a ubiquitous concern, it is unclear what effect this pandemic is having on hospitalized patients who are not infected with the SARS-CoV-2 virus. We seek to estimate the […]

Background: Sepsis is a leading health care burden associated with high mortality in the United States. Poor outcomes associated with sepsis continue despite modifications in the sepsis care guidelines. Several factors influence the outcome of sepsis including patient characteristics, etiology of sepsis, and management in the appropriate intensive care unit setting. The aim of our […]

Background: Sepsis is one of the leading causes of admission to intensive care units (ICU), and it is one of the most expensive conditions treated in United State Hospitals accounting for $20.3 billion or 5.2% of total hospitalization cost. Idiopathic pulmonary fibrosis (IPF) is one of the leading causes of interstitial lung disease, with currently […]

Background: Timely identification and treatment are integral to sepsis management in emergency department (ED) and inpatient settings. Increasingly, automated alerts embedded in electronic health records (EHRs) are used to expedite sepsis detection but may lead to false alarms and increased alarm fatigue. Additionally, recent data have demonstrated that the EPIC Sepsis Model—a proprietary sepsis alert […]

Background: Coronavirus disease 2019 (COVID-19) is an infectious disease that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1. On February 29, 2020, the first United States reported its first death3. On March 8, St. Louis County and Missouri saw their first case4. Despite ample research coming out about COVID-19, its causes, and its […]

Background: Previous studies have identified racial differences in sepsis incidence and sepsis mortality. Some evidence points towards differential treatment and subsequent sepsis outcomes in Black versus White patients. However, it is unclear to what extent racial differences exist in presentation and subsequent interpretation of complaints in the early phase of sepsis. Using History and Physical […]

Case Presentation: A 63-year-old woman was initially admitted for sore throat and dysphagia. At that time, workup revealed right parapharyngeal cellulitis, and she completed a 10-day course of levofloxacin. One month after discharge, the patient presented with a bilateral frontotemporal headache, blurred vision OS, and right otalgia for 2 days. Physical exam was remarkable for […]

Background: Sepsis, a life-threatening organ dysfunction caused by dysregulated host responses to infection (1), remains a major healthcare problem, affecting millions of people worldwide. Out of 48.9 million cases in 2017, 11 million people died, contributing to almost 20% of global deaths (2). Septicemia/sepsis was the most expensive condition treated hospitals in 2016 (3). These […]

Case Presentation: A 56-year-old male with a past medical history of large B cell lymphoma on ibrutinib with recently diagnosed COVID pneumonia, and recurrent ascites due to portal hypertension, presented to the hospital due to shortness of breath, and fever for one week. Physical examination was unremarkable on admission except for fever. His initial labs […]