Background: Stroke is the leading cause of mortality worldwide. However, available treatment options are limited due to the narrow treatment time window and reperfusion injury after revascularization. New treatment modalities to overcome these challenges are in need. Chlorpromazine and promethazine (C+P) have been utilized for cerebral edema, central high fever with restlessness, and delirium [1, […]

Background: Stroke is one of the most common causes of adult mortality. With changes in lifestyle, the increase in risk factors is leading to an increase in the number of cases. Mean platelet volume (MPV) is associated with an increase in platelet size and hence increased production of pro-inflammatory cytokines and increased expression of platelet […]

Background: Approximately one-third of patients with acute ischemic stroke (AIS) develop hyperglycemia regardless of pre-existing history of diabetes [1]. Hyperglycemia is associated with increased risk of hemorrhagic transformation and can be considered as a predictor of poor functional outcome after intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) [2]. Additionally, risk of death, hemorrhagic complications, and […]

Background: Patent Foramen Ovale (PFO) is a common abnormality that affects between 25% and 34% of the general population. For most people, it is a benign finding; however, in some, the PFO can be wider, allowing a paradoxical embolus to transit from the venous to the arterial circulation, which is associated with cryptogenic stroke, migraine, […]

Background: Ischemic stroke (IS) is a cerebrovascular disease with high incidence and mortality. White matter repair plays an important role in the long-term recovery of neurological function after cerebral ischemia. Neuroprotective microglial responses can promote white matter repair and protect ischemic brain tissue. The aim of this study was to investigate whether hypoxic post-conditioning (HPC) […]