Case Presentation: Diclofenac is a routinely prescribed non-steroidal anti-inflammatory agent in hospital with well-recognized hepatotoxic potential. However, there are only two reported cases of topical diclofenac-induced liver injury in literature. Herein, we describe a case of a 94-year-old man with Paget’s disease and osteoarthritis, who developed acute hepatotoxicity after four months of application of topical [...]