Case Presentation: We present a case of secondary Hemophagocytic Lymphohistiocytosis (HLH) triggered by Epstein-Barr Virus (EBV) in a 49 old male with no significant past medical history who worked as a cruise ship crewmember, presenting with high grade fevers and night sweats. Given his occupation, a broad differential diagnosis was initially considered, complicating timely diagnosis. [...]