Background: More frequently, clinicians encounter patients with mild-to-moderate COVID-19 (defined as patients whose oxygen saturation remains above 94% on room air)1 in the hospital setting.2 These patients may have acquired COVID-19 in the hospital or have tested positive for COVID-19 while presenting to the hospital for another condition.3 Many of these patients are high risk [...]

Case Presentation: We present the case of a 41-year-old male with a history of latent syphilis and recently diagnosed (about 10 days before admission) human immunodeficiency virus (HIV) and Mpox who presented to the ER with malaise, lethargy, and worsening cutaneous lesions. Clinical exam was notable for widespread skin lesions and purulent drainage from a [...]