Case Presentation: This case investigates the etiology of acute interstitial nephritis (AIN) in a metastatic melanoma patient who was transitioned from immune-checkpoint inhibitors (ICIs) to targeted BRAF-MEK inhibitors (BRAFi/MEKi). A 73-year-old man with cutaneous melanoma with lung metastases presented to the emergency room for generalized weakness, fevers, and renal failure. Six weeks prior to his [...]

Case Presentation: A 70-year-old man treated with Nivolumab for metastatic melanoma, presented with mild nausea and vomiting for a few days. He denied a change in urine output or appearance of urine, flank pain, or difficulty urinating. Creatinine on admission was 8.9 mg/dl (baseline 0.8mg/dl). Urinalysis revealed mild proteinuria, 21-50 WBCs/hpf. Spot protein/creatinine ratio was [...]

Case Presentation: A 68-year-old male with history of IgG4-related autoimmune pancreatitis presented to the Emergency Department with a one-month history of generalized weakness and a 25 lb unintentional weight loss over the past three months. Labs were notable for elevated lactate (3.4 mmol/L), new thrombocytopenia (platelets 29 ×10^9/L), and a stage II acute kidney injury [...]