Background: Venous thromboembolism (VTE) is a preventable and potentially fatal condition for which hospitalized medical patients are at risk. Compared with the more traditional option of unfractionated heparin, low molecular weight heparin (LMWH) has been shown to be superior for VTE prophylaxis with regard to both efficacy and bleeding risk, and to have a lower [...]

Background: Thrombocytopenia is common in hospitalized patients. Heparin Induced thrombocytopenia (HIT) is a life threatening condition which can lead to extensive thrombosis. Diagnosis of HIT relies on clinical suspicion determined by 4T score, and the immunoassays through testing for anti PF4/Heparin antibodies. Clinical practice guidelines published by the American Society of Hematology (2013) recommended to [...]

Background: Heparin-Induced Thrombocytopenia (HIT) is a rare (0.1-1% of heparinized medical patients) but devastating (up to 10% mortality) side-effect of heparin administration[1].  In thrombocytopenic patients, the pre-test probability of HIT is estimated by the validated “4Ts Score”, which is used to risk-stratify patients into Low (0-3 points), Intermediate (4-5 points), and High (6-8 points) likelihoods [...]