Background: In the dawning era of precision medicine, increasingly sophisticated tools are becoming available to diagnose and investigate rare and unexplained diseases. The application of these tools to clinical practice will require new models of collaboration between clinicians, tool developers, and laboratory investigators. Many structural barriers to such collaboration exist in our current healthcare delivery [...]

Background: In the dawning era of precision medicine, increasingly sophisticated tools are becoming available to diagnose and investigate rare and unexplained diseases. The application of these tools to clinical practice will require new models of collaboration between clinicians, tool developers, and laboratory investigators. Many structural barriers to such collaboration exist in our current healthcare delivery [...]