Case Presentation: Cardiac amyloidosis- a multiorgan disease, which carries a grave prognosis due to its rarity and nonspecific presentation. We report a case of systemic AL amyloidosis with predominant cardiac and renal involvement associated with multiple myeloma.• A 60-year-old male presented with progressively worsening anasarca including 3+ pitting edema in all extremities, and 80 lbs. [...]