Background: Heparin-induced thrombocytopenia (HIT) syndrome is an immune-mediated disorder producing thrombocytopenia and thrombosis, with or without prior exposure to heparin. Although avoidance of heparin products and non-heparin anticoagulants are used, immune-based therapies including intravenous immunoglobulin have been tried when the thrombocytopenia persists or there is breakthrough thrombosis. We sought to systematically review and analyze the [...]

Case Presentation: A 55-year-old female presented with headaches and intermittent fevers. On initial examination, she had left hand weakness. Laboratory findings revealed leukocytosis; brain MRI demonstrated multiple bilateral cerebral infarcts. Initial workup was concerning for embolic stroke which initiated our search for a cardioembolic source. No significant abnormalities were seen on transthoracic echo (TTE) and [...]

Case Presentation: A 46-year-old female presented with a 2-day history of shortness of breath, pleuritic chest pain and lower extremity swelling while taking low-molecular weight heparin (LMWH). One month prior she was diagnosed with a left lower extremity DVT after a hysterectomy. She was treated with LMWH with a planned transition to rivaroxaban. Medical history [...]