Background: Myelofibrosis is a chronic myeloproliferative neoplasm characterized by progressive bone marrow fibrosis and extramedullary hematopoiesis leading to splenomegaly. Progressive splenomegaly is common in advanced myelofibrosis, and spleen volume is a predictor of survival. The oral selective small-molecule JAK 1/2 inhibitor ruxolitinib is used for symptomatic management of intermediate-2 and high-risk myelofibrosis, and leads to […]

Case Presentation: A 30‐year‐old woman was admitted with fever and headache. On physical examination temperature was 101.5°F; the jolt accentuation test was positive. Routine laboratory studies and head CT were normal. CSF analysis showed 220 WBC (98% lymphocytes), normal protein and glucose. Laboratory test results are summarized in the table. The patient was treated with […]

Case Presentation: A 76-year-old Chinese woman with history of cryptogenic cirrhosis (MELD-Na 25) presented to our hospital with 1 week of worsening jaundice, abdominal distension, and right upper quadrant pain. Cirrhosis was diagnosed by imaging on admission 2 months previously and presumed to be secondary to Hepatitis C infection due to antibody positivity. CT of […]

Case Presentation: A 42 y/o Hispanic female with a history of IV drug abuse and dermatitis since 2005 with recurrent episodes of cellulitis presented to the hospital with severe edema, erythema and pain of the right lower extremity for 3 days. She had been treated with steroid injections and topical steroids intermittently for her dermatitis […]