Background: Until the advent of novel oral anticoagulants (NOACs), Warfarin was the only oral agent available for the treatment of deep venous thrombosis (DVT) and Pulmonary embolism (PE). Bridging with parenteral anticoagulation until warfarin reaches a full therapeutic level often results in prolonged hospitalization. Rivaroxaban, Dabigatran, Apixaban, Edoxaban were approved by the FDA for DVT [...]

Case Presentation: A 59-year-old man with a history of a chronic provoked bilateral pulmonary embolism with left lower extremity deep vein thrombosis (DVT), Non-ST-elevation myocardial infarction and hypercholesterolemia presented to the emergency department with acute, severe, constant left calf pain and swelling, exacerbated by standing. He stated that “I think I have another blood clot [...]