Background: Factor concentrates such as 4 factor-prothrombin complex concentrate (4F-PCC) are commonly used off-label as reversal agents in factor Xa inhibitor-associated bleeding events. However, there have been limited studies on the efficacy and safety of 4F-PCC use in these settings. We conducted a retrospective observational study of the use of 4F-PCC for major bleeding occurring [...]

Case Presentation: A 46-year-old female presented with a 2-day history of shortness of breath, pleuritic chest pain and lower extremity swelling while taking low-molecular weight heparin (LMWH). One month prior she was diagnosed with a left lower extremity DVT after a hysterectomy. She was treated with LMWH with a planned transition to rivaroxaban. Medical history [...]

Case Presentation: An 87-year-old man with medical history significant for hypertension, non-ischemic cardiomyopathy, paroxysmal atrial fibrillation (anticoagulated on Rivaroxaban) and ventricular tachycardia (recently started on Amiodarone) presented to the emergency room with chest pain. He reported that the pain started insidiously 2 days prior to presentation, pleuritic, sharp, retrosternal and intermittent, associated with diaphoresis and [...]