Case Presentation: A 49-year-old male with primary sclerosing cholangitis and newly diagnosed locally advanced cholangiocarcinoma was initiated on 5-Fluorouracil (FU) based chemotherapy (FOLFOX) as an outpatient (Figure 1). Within one day of receiving FOLFOX, the patient presented to the ED with acute, intermittent chest pain radiating to his left arm and shortness of breath. Vital [...]

Case Presentation: A 63-year-old woman with a history of Lynch Syndrome who presented with acute chest pain. Her Lynch Syndrome manifested with invasive moderately differentiated adenocarinoma of the sigmoid colon managed with hemicolectomy as well as 9 cycles of Leuocoverin, 5-Fluorouriacil (5-FU) and oxaliplatin (FOLFOX) and prophylactic total hysterectomy and bilateral salpingo-oophorectomy. She completed her [...]

Case Presentation: A 75-year-old man presents with altered mental status for one day. On exam, patient was nonverbal, opening eyes spontaneously, and responsive to painful stimuli. CT head, chest x-ray, urinalysis, blood cultures, urine cultures, metabolic panel, blood counts, and toxicology screen were all not significant for acute findings.The patient has a history of stage [...]

Case Presentation: A 43-year-old Caucasian woman with stage IV rectal adenocarcinoma metastatic to liver and lung presented with new onset generalized tonic clonic seizures. She was receiving her second line treatment with 5-FU continuous infusion Day number 7 of 7 of the 5th cycle. This was preceded by confusion and altered mentation since the previous [...]

Case Presentation: A 40-year-old Caucasian male presented with a recent diagnosis of stage IV metastatic duodenal adenocarcinoma. Given the metastatic disease, after duodenal stent placement, the patient started on adjuvant mFOLFOX6 chemotherapy. During the second day of the first cycle of chemotherapy, the patient suddenly experienced complete right-sided weakness, headache, confusion, and slurred speech. He [...]