Case Presentation: A 77-year-old African-American male with Adult-onset Still’s disease (AOSD) was admitted at the hospital for severe thrombocytopenia. The patient had been diagnosed with AOSD four years before this hospital admission. His AOSD was well-controlled with anakinra, an interleukin-1 receptor antagonist, and low-dose prednisone. On admission, the patient did not have any neurological manifestation. [...]

Case Presentation: A 29-year-old female with a past medical history of microcytic anemia and recently-diagnosed AOSD presented with 2 weeks of progressive dyspnea. On her preceding hospital admission, her AOSD was diagnosed and clinical suspicion for MAS was initially mounted. At that time, she demonstrated polyarthralgia, pruritic rash, high-grade fevers, hepatosplenomegaly, diffuse lymphadenopathy, neutrophilic leukocytosis, [...]

Case Presentation: A 38-year-old male with presumed seronegative rheumatoid arthritis (RA), irritable bowel syndrome with diarrhea (IBS-D), and reported Lyme disease (negative serology) presented with acute dyspnea, pleuritic chest pain, and chronic relapsing fevers. Initial treatment with broad-spectrum antibiotics failed, and he developed acute hypoxic respiratory failure, requiring transfer to the Medical Intensive Care Unit [...]