Case Presentation: A 24-year-old Caucasian female with a family history of multiple autoimmune disorders presented with 3 weeks of bruising, petechiae, fatigue, and outside labs that revealed significant anemia and thrombocytopenia. Admission workup showed Hgb 7.6, platelets (PLT) < 3,000, and elevated MCV. Further labs showed elevated LDH, indirect bilirubinemia, haptoglobin< 10, and positive DAT [...]

Case Presentation: A 65-year-old woman with a history of early-stage breast cancer—was treated six years prior. She was subsequently admitted multiple times over the following years for pancytopenia, which was thought to be multifactorial—due to nonalcoholic steatohepatitis and auto-immune hemolytic anemia (AIHA). Therefore, she received a supportive blood transfusion, intravenous immunoglobulins, and rituximab for suspected [...]

Case Presentation: A 84-year-old woman with a past medical history of HTN, DM2, CHF, and hypothyroidism presented to an offsite ED after falling on her buttock when rising from a kitchen chair. She had an uneventful course of COVID-19 four weeks prior. Over the last 2 weeks, she developed progressive weakness. Upon arrival at the [...]

Case Presentation: 81-year-old man initially presented to his primary care physician for a persistent cough of three weeks associated with new onset shortness of breath when climbing stairs. He had a normal chest X-Ray, but also a mild anemia. Initial work-up was targeted at evaluation for a gastrointestinal bleed. He underwent a CT abdomen/pelvis, upper [...]

Case Presentation: A 66-year-old female with metastatic small cell lung cancer involving brain, liver, and bones was admitted via ED with generalized weakness, mild confusion, and decreased oral intake for 3 days. She was initiated on immunotherapy with immune checkpoint inhibitors, ipilimumab (human cytotoxic T-lymphocyte antigen 4 (CTLA-4)-blocking antibody) and nivolumab (a programmed death receptor-1 [...]

Case Presentation: A 27 year old previous healthy male presented to the Emergency Department with 4 days of progressive fatigue and scleral icterus. These symptoms were preceded by 2 days of a nonproductive cough. Upon presentation, the patient’s labs were notable for an indirect hyperbilirubinemia of 5.9 mg/dL. Complete blood count revealed a macrocytic anemia [...]

Case Presentation: A 39-year-old obese man with type 2 diabetes, dyslipidemia, and hypertension presented to the ED with intermittent abdominal pain, diarrhea, nausea, and emesis 2 weeks after an illness with sore throat. He denied fever, chills, shortness of breath, epistaxis, gum bleeding, or easy bruising. Medications included losartan-hydrochlorothiazide, metformin, and tirzepatide. Vital signs showed [...]

Case Presentation: A 22-year-old female with a history of immune thrombocytopenia (ITP) and asthma presented with fever, altered mental status, and bilateral lower extremity petechiae. She was previously taking hydroxychloroquine daily for ITP but discontinued it on her own eight months prior. She denied any new medications, recent animal exposures, insect bites, trauma, or recent [...]

Case Presentation: A 43-year-old African-American female with a history of multiple sclerosis complicated by paraplegia, neurogenic bladder, and seizures presented to the hospital with a syncopal episode and was found to have a hemoglobin of 2.9 (12.0 to 16.0 gm/dL) with red blood cell count RBC 0.96 (4.00 – 5.20×10^6/uL), lactate dehydrogenase 639 (