Case Presentation: A 70-year-old man treated with Nivolumab for metastatic melanoma, presented with mild nausea and vomiting for a few days. He denied a change in urine output or appearance of urine, flank pain, or difficulty urinating. Creatinine on admission was 8.9 mg/dl (baseline 0.8mg/dl). Urinalysis revealed mild proteinuria, 21-50 WBCs/hpf. Spot protein/creatinine ratio was [...]

Case Presentation: An elderly man was diagnosed with clear cell renal cell carcinoma in 1987, and treated with left nephrectomy, though developed multi-organ metastatic disease in 2015. After he did not tolerate initial treatment with sunitinib, he received 15 cycles of NKTR-214 and nivolumab as part of a phase I/II study. Three months after his [...]