Case Presentation: This case describes a 63-year-old male who was recently diagnosed with renal cell carcinoma with metastasis to the lungs confirmed with a biopsy showing diffuse PAX-8 positivity on an immunohistochemical staining panel favoring renal origin. He was started on Nivolumab/Ipilimumab however was hospitalized in the intensive care unit for septic shock due to [...]

Case Presentation: A 76-year-old female with a history of hypertension, BMI 48 kg/m2, hypothyroidism, and metastatic melanoma presented with a 2-week history of progressive myalgia, weakness, and dyspnea 3 weeks after the first infusion of nivolumab and relatlimab.In July 2019, she was diagnosed with stage IIB (cT4a, cN0, cM0) melanoma of the left leg (4.2 [...]

Case Presentation: A 70-year-old man treated with Nivolumab for metastatic melanoma, presented with mild nausea and vomiting for a few days. He denied a change in urine output or appearance of urine, flank pain, or difficulty urinating. Creatinine on admission was 8.9 mg/dl (baseline 0.8mg/dl). Urinalysis revealed mild proteinuria, 21-50 WBCs/hpf. Spot protein/creatinine ratio was [...]

Case Presentation: An 80-year-old male with a history of atrial fibrillation post-ablation on apixaban, COPD, hypertension, and Stage IIIC malignant melanoma post-immunotherapy with nivolumab complicated by non-resolving pneumonitis presented with worsening dyspnea and tachycardia. In the ED, he was found to have atrial flutter with rapid ventricular response (RVR), elevated high-sensitivity troponin, and brain natriuretic [...]

Case Presentation: An elderly man was diagnosed with clear cell renal cell carcinoma in 1987, and treated with left nephrectomy, though developed multi-organ metastatic disease in 2015. After he did not tolerate initial treatment with sunitinib, he received 15 cycles of NKTR-214 and nivolumab as part of a phase I/II study. Three months after his [...]