Background: Approximately 5-10% of the US population reports a Penicillin (PCN) allergy. Only 1 in 10 of these patients are found to have a positive reaction to PCN. This label comes at a grave cost, with higher incidences of multidrug-resistant nosocomial infections reported among these patients. With the lack of novel antibiotics and the alarming [...]

Background: Approximately 5-10% of the US population reports a Penicillin (PCN) allergy. Only 1 in 10 of these patients are found to have a positive reaction to PCN. This label comes at a grave cost, with higher incidences of multidrug-resistant nosocomial infections reported among these patients. With the lack of novel antibiotics and the alarming [...]

Background: Penicillin discovered in 1928 by Sir Alexander Fleming, beginning of the antibiotic revolution. Penicillin as helped increase average life Span in USA from 47 years to 78.8 years. Beta lactam account to about 40% of total antibiotic use every year. 10% of patients in U.S. report penicillin allergy, but 9 out of 10 patients [...]

Background: Ceftriaxone or cefotaxime has been the drug of choice to treat spontaneous bacterial peritonitis (SBP) for many years, but little is known about microbiology, resistance rate to cephalosporines, and clinical outcomes over the last few decades. Our study aimed to describe the clinical and microbiological characteristics of culture-positive SBP at University of Kentucky Hospital. [...]

Case Presentation: A 47-year-old previously healthy male was referred from another hospital with fever, dry cough, abdominal pain and diarrhea for about one month. He also had unintentional weight loss of 33 lbs and abdominal distention over 2 months. He was originally from Nigeria and had moved to Japan 10 years ago. A physical exam [...]

Case Presentation: A 51-year-old man with history of alcoholic cirrhosis presented with diarrhea, abdominal pain, fatigue and confusion for one week. Vitals were within normal limits, though the patient reported subjective fevers at home. Physical exam was notable for asterixis and ascites, and a paracentesis was performed. Cell count and culture of his ascitic fluid [...]

Case Presentation: An 88-year-old male presented to the emergency department (ED) for dyspnea. Of note, patient is from nursing home (NH) and history was obtained from nurse (RN). RN notes that he was at baseline, talkative and pleasant. He had tested positive for COVID as NH had outbreak, and then weakened over a few days. [...]