Case Presentation: A 50-year-old female with a history of alcohol use disorder presented to the emergency department with a one-day history of unsteady gait, decreased lower extremity sensation, and slurred speech. She reported using 20 whippits (recreational inhaled nitrous oxide) daily for the preceding 3-4 weeks. She denied any dietary restrictions. Exam revealed 3+ patellar [...]

Case Presentation: A 32-year-old man with a remote history of alcohol and cocaine use disorders, depression and morbid obesity presented to hospital with numbness in the upper and lower extremities occurring over several months. His symptoms began with numbness and paresthesias in the hands and feet which was intermittent but became constant and spread proximally [...]

Case Presentation: A 27-year-old male without medical history presented with paresthesias in his hands and feet, and numbness and instability from his waist down for 4 days. The patient initially denied any illicit substances, had no dietary restrictions, and no known medical problems in the family. Cervical MRI revealed T2 dorsal column hypersensitivity consistent with [...]

Case Presentation: A 17 year-old male with a history of marijuana and nitrous oxide use presented with 4 days of paresthesia in his bilateral lower extremities, sudden onset-ataxia, gait instability, and genital numbness extending to his extremities. Comprehensive infectious and neurologic workup for Guillain-Barré syndrome, transverse myelitis, and other neuropathies all returned negative. Magnetic resonance [...]

Case Presentation: A 34-year-old male with no past medical history was hospitalized for progressive weakness, numbness, and tingling of his extremities for 2 weeks. He denied fevers, headache, neck pain, or bowel/bladder complaints. He smoked 10 cigarettes and drank 24 to 48 oz beer daily. He admitted to social marijuana and cocaine use. He worked [...]

Case Presentation: A 22-year-old woman with no known medical history presented with visual hallucinations, confusion, and jaundice. Her friend reported chronic nitrous oxide (N₂O) inhalation, escalating to three cans per day over the prior month. This increase coincided with a recent job loss and worsening mood. Days before admission, over 100 empty N₂O cans were [...]