Background: Obesity is associated with many cardiopulmonary comorbidities independently associated with worse health outcomes in acute illness, yet the physiological mechanisms potentially making obese patients more susceptible to COVID-19 remain uncertain. Adiposity-derived immunosuppression, increased thrombogenic potential, and predilection towards inflammatory hyperreactivity have all been postulated as potential mediators of this phenomenon. Yet, the most obvious [...]

Background: Obesity is associated with overall higher mortality risk in the general population however, some authors have noted patterns to suggest a survival advantage in a certain clinical subpopulation. Obesity paradox is reported for stroke, myocardial infarction, heart failure, renal disease, and diabetes. Clostridium difficile infection (CDI) is the most common nosocomial infection in the [...]

Background: The obesity paradox describes a counterintuitive observation of improved outcomes in patients with obesity. Analysis of the association among overweight/obesity and leading causes of inpatient mortality in a systemic manner has not been conducted. Methods: We used STATA (StataCorp, College Station, Texas) to analyze the 2016 National Inpatient Sample (NIS). We recognized patients with [...]

Background: The Obesity Paradox postulates that obesity is a protective factor against mortality in certain chronic conditions such as chronic kidney disease (CKD) and congestive heart failure. Although this paradox is established in CKD, few studies have analyzed the paradox in acute kidney injury (AKI). There are both short and long term ramifications to AKI [...]