Background: Drug induced long QT syndrome is quite common in daily clinical practice but its impact is unknown. Methods: We searched the PubMed and EMBASE databases (until May 2nd, 2017) to identify studies reporting drug induced Long QT syndrome and followed the PRISMA guidelines. The main outcomes measured in these studies were QTc prolongation, Ventricular [...]

Background: It is common practice to monitor QTc interval in hospitalized patients newly started on antipsychotics. While some guidelines exist for frequency of ordering EKGs in the outpatient setting, these may not apply to inpatients due to comorbid electrolyte disturbances or addition of other new medications. There are no evidence-based guidelines for QTc monitoring frequency [...]

Background: Antipsychotics can prolong QTc interval and lead to development of the fatal arrhythmia Torsade de Pointes. Accordingly, serial EKG monitoring of QTc in patients newly started on antipsychotics has become common practice in hospitals. By current standards, medical management of antipsychotic therapy is clinically indicated when QTc > 500ms and/or there is an increase [...]

Case Presentation: A 37 year-old woman with a past medical history of depression and chronic knee pain presented with complaints of two day duration non-radiating 8/10 epigastric and lower abdominal pain associated with nausea and vomiting. Vitals sings were normal. Abdomen was soft, non-distended with generalized tenderness, but without masses, rebound, or guarding. Lipase was [...]

Case Presentation: A 57-year-old male with past medical history of alcohol-induced chronic pancreatitis complicated by chronic pain, opioid use disorder (OUD) on methadone, and depression on sertraline presented to the emergency department with dizziness, dyspnea, and nausea. About six months prior to admission, he had been transitioned from buprenorphine to methadone for better pain control. [...]