Background: Drug induced long QT syndrome is quite common in daily clinical practice but its impact is unknown. Methods: We searched the PubMed and EMBASE databases (until May 2nd, 2017) to identify studies reporting drug induced Long QT syndrome and followed the PRISMA guidelines. The main outcomes measured in these studies were QTc prolongation, Ventricular [...]

Case Presentation: A 20-year-old male with past history of asthma presented initially with bloody diarrhea and subjective fever of one day’s duration. Upon evaluation vital signs revealed temperature of 103 F, and tachycardia. On physical examination there was generalized abdominal tenderness with normal bowel sounds. Thrombocytopenia was present with platelet count of 46 k/ul. Antibiotics [...]

Case Presentation: Diclofenac is a routinely prescribed non-steroidal anti-inflammatory agent in hospital with well-recognized hepatotoxic potential. However, there are only two reported cases of topical diclofenac-induced liver injury in literature. Herein, we describe a case of a 94-year-old man with Paget’s disease and osteoarthritis, who developed acute hepatotoxicity after four months of application of topical [...]

Case Presentation: Pyroglutamic acid (5-oxoproline) is a rare cause of metabolic acidosis most often associated with sub-acute or chronic acetaminophen intake in the presence of unique risk factors. Discussion: A 25-year old female with Crohn’s disease presented with one month of worsening abdominal pain, diarrhea, and anorexia with reported 20 kg weight loss. She developed [...]

Case Presentation: A 42 year old gentleman with past medical history of anxiety and depression presented with acute psychosis, hypertensive urgency, tachycardia and worsening agitation ultimately needing sedation and intubation. He was found to be oliguric with an elevated creatinine of 6.69 with a baseline normal kidney function. After failing a diuretic challenge, the patient [...]