Background: In medical care for older patients, the presence of potentially inappropriate medications (PIMs) is associated with increased adverse outcomes [1, 2]. A wide range of medications with anticholinergic properties affects cognitive states of older patients have been regarded as PIMs [1, 3]. We purposed to assess clinical impact of anticholinergic cognitive burden on clinical [...]

Background: People living with HIV (PLWH) are now anticipated to have near-normal life expectancies. With increased longevity comes the higher burden of non-infectious comorbidities related to the chronic immune activation and premature telomere shortening in PLWH, ranging from dyslipidemia to osteoporosis [1]. Increased comorbidity burden can lead to polypharmacy, defined as the concurrent use of [...]

Case Presentation: A 65-year-old woman with hepatitis C-induced liver cirrhosis status-post liver transplantation, coronary artery disease and gout, presents with one week of progressive fatigue, weakness, and severe pain in her right leg and left shoulder. She was on atorvastatin for cardiac disease and had recently started Ledipasvir/Sofosbuvir for hepatitis C two months prior. She [...]

Case Presentation: A 75-year-old white male presented to the Emergency Department with a 2-day history of gait disturbance, flailing bilateral upper extremity movements, and confusion. His wife stated that his symptoms had been occurring for the past 1 month and acutely worsened over the past several days. For the past year, he had been evaluated [...]