Background: Antibiotics used to treat Clostridioides difficile infection (CDI) can predispose patients to recurrent CDI (rCDI). Gut microbiome restoration by fecal microbiota transplantation is recommended by multiple guidelines after ≥2 episodes of rCDI, with no guideline-recommended options to restore the microbiome earlier in the course of CDI. RBX2660 is a standardized, microbiota-based live biotherapeutic being [...]

Background: Clostridioides difficile is an opportunistic pathogen that causes an estimated 500,000 infections per year in the United States. RBX2660, a standardized, microbiota-based live biotherapeutic, is being investigated as a treatment option for recurrent C. difficile infection (rCDI). RBX2660 has demonstrated consistent tolerability and efficacy in reducing rCDI across 6 clinical studies. We present a [...]

Background: Diabetic ketoacidosis (DKA) remains one of the commonest causes of medical and intensive care unit hospitalisations. DKA is a preventable hospital admission which is associated with multiple modifiable risk factors. However, little is known about factors that can predict healthcare resource utilisation in DKA. Previous studies have explored clinical and biochemical factors affecting the [...]

Case Presentation: 73-year-old man was diagnosed with immune thrombocytopenia (ITP) in 2011 and was treated with intravenous immunoglobulin (IVIG), high dose steroid, rituximab and romiplostim to which he responded and subsequently was weaned off of azathioprine and steroid and achieved remission starting 2012. Eight weeks after receiving second dose of Pfizer’s BNT162b2 vaccination, he noted [...]

Background: Clostridioides difficile infection (CDI) is a leading healthcare-associated infection causing debilitating diarrhea, life-threatening complications, 20,500 deaths and healthcare costs of up to $5.4 billion annually in the US. The main driver of CDI costs is hospitalizations, and patients with higher CDI recurrence rates have more hospitalizations and emergency department visits and longer hospital stays. [...]

Case Presentation: A 32-year-old male with a history of alcohol use disorder presented with dull epigastric pain, fever, and chills. Physical examination revealed moderate epigastric tenderness. Laboratory findings included WBCs 14.6×10⁹/L, Hb 12.5 g/dL, INR 1.4, with normal liver enzymes. MRI of the abdomen demonstrated a 6.7×6.6 cm lesion in the right hepatic lobe with [...]