Background: The overdose epidemic in the United States has seen a significant rise in deaths associated with antidepressants in the last two decades. This study examines mortality trends related to antidepressants in adults aged >25 years between 1999 and 2020 across various demographics. Methods: Analysis of poisoning by anti-depressants-related deaths in the US from the [...]

Background: Inpatient hypoglycemia (HG) is common and often avoidable, associated with poor outcomes and high costs, and its prevention reflects hospital performance. We investigated its risk factors and impact on mortality, hospital length of stay (LOS), charges, and readmissions. We defined HG as glucose ≤40 mg/dl (severe), >40 – ≤70 mg/dl (moderate), or euglycemia >70 [...]

Background: The Surviving Sepsis Campaign strongly recommends that all hospitals screen for sepsis as part of performance improvement. The effect of screening for sepsis on mortality, length of stay, and time to antibiotics is uncertain. Methods: A systematic literature search was conducted using Cochrane Library, Google Scholar, Ovid Embase, Ovid Medline, Scopus, and Web of [...]

Background: Intrahepatic cholangiocarcinoma (IHCC) is the second most prevalent type of primary liver malignancy and has less than a 25% 5-year survival rate. Over the last two decades, the incidence of IHCC has been on the rise, however, the trends in mortality related to this form of malignancy are yet to be explored. Therefore, our [...]

Background: In 2022, healthcare spending in the US accounted for 17.3% of its GDP(1), yet the US ranked near the bottom among high-income nations for key health outcomes. It is unclear if a similar relationship exists between spending and health outcomes across US Hospitals. Centers for Medicare and Medicaid Services (CMS) reports a standardized risk-adjusted [...]

Background: In the management of transplant-ineligible multiple myeloma (MM), therapeutic strategies are crucial for improving patient outcomes. Recent clinical trials have explored the efficacy of triplet vs dual therapy in this context. This meta-analysis aimed to evaluate the comparative effectiveness (overall survival [OS], progression-free survival [PFS], minimal residual disease [MRD] negative, and response rate [RR]) [...]

Background: Post-surgical procedure-related mortality is a critical area of healthcare, frequently linked to complications such as excessive bleeding, sepsis, organ failure or adverse reactions to anesthesia. Given the devastating nature of these complications and their effects on patient safety, the importance of robust surgical protocols and post-op monitoring is highlighted. This study analyzed trends and [...]

Background: Preoperative diastolic dysfunction has been proposed as an independent predictor of major adverse cardiac events (MACE) and death after non-cardiac surgery. However, most studies supporting this association have included non-emergent procedures and utilized E/e’ ratio as the predominant echocardiographic variable evaluating diastolic function. Compared to patients undergoing elective surgeries, hip fracture surgery patients are [...]

Background: Hip fracture surgery is associated with a significant incidence of postoperative myocardial infarction (postop-MI) up to 14% in the first 7 days after repair. Patients who sustain postop-MI have 1-year mortality rates up to 36%. However, the impact of risk factor modification and routine troponin monitoring on the incidence and prognosis of postop-MI remains [...]